From laboratory experiments analyzing song bird sound evolution that shed light on the nature of intelligence to how cancer cell mobility mechanics work, the QSBC is involved with a variety of multi-disciplinary projects and activities.
Awarded to:
Rebecca Ihrie, Ph.D.
Associate Professor, Cell & Developmental Biology
Vanderbilt University
J.T. O'Connor, A.C. Stevens, E.K. Shannon, F.B. Akbar, K.S. LaFever, N.P. Narayanan, C.D. Gailey, M.S. Hutson, A. Page-McCaw “Proteolytic activation of Growth-blocking peptides triggers calcium responses through the GPCR Mthl10 during epithelial wound detection” Developmental Cell 2021 Jul 14: S1534-5807(21)00527-X. https://doi.org/10.1016/j.devcel.2021.06.020
Summary
We’re here to rewrite the story of brain cancer. Let’s empower patients to take their lives back.
The Japanese Core-to-core meeting titled "Fusion of Mathematics and Biology" was held online (via Zoom webinar) during October 26-28, 2020. Some participants gathered at an actual venue set up in Osaka University, Japan.
A Vanderbilt cancer systems biology team has identified the enzymes that keep tumor cells growing in the presence of drug treatment, opening the door to stopping these cells dead in their tracks.
Rebecca Ihrie keynoted the Fluidigm Mass Cytometry Summit on 9/23.
The 2020 Junior Investigator (JI) Meeting for the NCI Cancer Systems Biology Consortium (CSBC), Physical Sciences – Oncology Network (PS-ON), and the Big Data Scientist Training Enhancement Program (BD-STEP) was held as a virtual meeting on August 27-28, 2020, bringing together systems biologists, physical scientists, and data scientists who work towards a better understanding of cancer and the resolution of fundamental questions in cancer research. This meeting aims to generate synergy between individuals with diverse skills and shared research interests.
Jérémie Marlhens joined Quaranta Lab from Ecole Normale Superieure De Lyon (France) as a visiting research intern for 6 months. Jérémie worked with Darren Tyson and Quaranta Lab and Lopez Lab students to learn rule-based mechanistic modeling using PySB.
Naotoshi Nakamura, Specially Appointed Associate Professor in the Center for Mathematical Modeling and Data Science at Osaka University in Japan, joined us as a visiting faculty member at Vanderbilt. Dr. Nakamura worked to develop a mathematical model of the EphA2 receptor pathway, in order to explore its switch-like bistable behavior [promoting vs. inhibiting cell proliferation] in response to microenvironmental factors.
Darren Tyson, with the help of Mark III, organized a Cell Imaging Hackathon from March 4th-6th, held near Vanderbilt's campus, and welcoming attendees across the Midwest and West Coast to Nashville. Accepted challenges included: Multi-panel image registration Segmentation (competition) Rare cell type identification Quantification of PD1 asymmetry Morphology-based cell type calling.
The Fisk-Vanderbilt Master’s to PhD Bridge Program works to improve the demographic representation in STEM. Wajiha Khalid took part in the program, joining the Quaranta Lab.
This group meets every month to foster a computational biology community within Vanderbilt on single-cell genomics, by creating an interactive discussion and bootcamp style demonstration of software in the field on generated data.
Single-cell Data Analysis Working Group meeting
This group meets every month to foster a computational biology community within Vanderbilt on single-cell genomics, by creating an interactive discussion and bootcamp style demonstration of software in the field on generated data.
Junior Investigator Meeting for the NCI Cancer Systems Biology Consortium
The 2020 Junior Investigator (JI) Meeting for the NCI Cancer Systems Biology Consortium (CSBC), Physical Sciences – Oncology Network (PS-ON), and the Big Data Scientist Training Enhancement Program (BD-STEP) was held as a virtual meeting on August 27-28, 2020, bringing together systems biologists, physical scientists, and data scientists who work towards a better understanding of cancer and the resolution of fundamental questions in cancer research. This meeting aims to generate synergy between individuals with diverse skills and shared research interests.