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Modeling Cell Signaling From Molecules to Macrostructures

February 14 @ 12:00 pm - 1:00 pm UTC-5

Cells use receptors on their surface to detect signals, such as hormones or growth factors, in their environment. These receptors then activate signaling pathways that transmit this information to the cellular machinery required to mount an appropriate response. Often this involves a change in cell shape or directed movement, and therefore requires regulation of the cytoskeleton. To investigate the mechanisms used by signaling pathways to regulate the cytoskeleton, we combine mathematical modeling with experimental investigations.  We present analyses of single-molecule measurements made using novel biosensors for Src kinase and Cdc42 to infer the chemical kinetics of these two signaling molecules. We then present mathematical models for signaling by Cdc42 to investigate its role in polarity establishment and phagocytosis.

Timothy Elston, Ph.D.
Professor of Pharmacology
Jeffery Houpt Distinguished Investigator
Co-Director, Computational Medicine Program
University of North Carolina

Hybrid Available – https://vanderbilt.zoom.us/j/99590807654
Passcode – 157605

Student and trainee lunch to immediately follow.

Please email rebecca.l.sykes@vanderbilt.edu with any questions.

Details

Date:
February 14
Time:
12:00 pm - 1:00 pm UTC-5
Event Category:

Venue

Bass Conference Room – RRB 436

Organizer

QSBC Seminar Series

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