Single-cell genomics technologies have been lauded for their potential to probe biological systems with cell type specificity, and to elucidate cellular differentiation trajectories. However, the analysis of single-cell genomics data is fraught with numerous computational challenges. I will show that biophysical models of transcriptional dynamics are helpful in resolving some of these challenges and outline a unifying mathematical framework for single-cell genomics.

Lior Pachter
Bren Professor of Computational Biology and Computing
Caltech