Moving the message: how mRNA transcripts are spatially patterned to direct developmental outcomes
September 22 @ 12:00 pm - 1:00 pm UTC-5
Gene expression involves the precise regulation of messenger RNA (mRNA) transcripts in space and time. In developing embryos, this process must be precisely executed to ensure cells adopt their proper cell fates and developmental outcomes. Dr. Osborne Nishimura’s lab explores how mRNA transcripts concentrate within biomolecular condensates or at membranes within the nematode Caenorhabditis elegans. Her group has identified two major modes of post-transcriptional mRNA localization. Her discoveries lend insights into the generalizable features of post- transcriptional mRNA localization, a concept that has historically been of interest as a central feature of many human neurological diseases. More recently, researchers are coming to appreciate that mRNA localization is more widespread than previously thought.
Erin Osborne Nishimura
Assistant Professor, Department of Biochemistry and Molecular Biology,
Colorado State University