Loading Events

« All Events

  • This event has passed.

Redox Systems Biology: Computational Strategies for Predicting Cancer Therapeutic Responses

March 27 @ 12:00 pm - 1:00 pm UTC-6

Despite the growing number of therapeutic options available for cancer patients, predicting which course of treatment will the best response for an individual is still a major challenge for precision medicine. In this talk, I will describe computational systems biology strategies that we have developed to investigate heterogeneity of drug metabolism among head and neck cancers. Our platforms range from genome-scale metabolic flux modeling to single cell kinetic models and agent-based simulations of tumor architecture. The common theme among these diverse approaches is exploring the role of redox systems in amplifying or suppressing cytotoxicity associated with oxidative damage induced by radiation or chemotherapeutics. We have developed scRNAseq transcriptome-to-phenotype models at the single cell level to determine reactive oxygen species formation associated with quinone cycling. Over 4000 individual simulations reflected significant systems-level differences between the redox states of healthy and cancer cells, demonstrating in some patient samples a targetable cancer cell population. In a subset of patients, statistically indistinguishable effects between non-malignant and malignant cells highlights the role of alternate antioxidant components in dictating drug-induced oxidative stress. Finally, spatial agent-based modeling has helped to identify organizational features of tumor required to fully realize the desired bystander effects of drug-induced reactive oxygen species formation that is observed in quinone-based cycling.

Melissa Kemp Ph.D.
Carol Ann & David Flanagan Professor, Biomedical Engineering
Georgia Institute of Technology

ON ZOOM ONLY – https://vanderbilt.zoom.us/j/93115023836
Passcode – 676830

Please email rebecca.l.sykes@vanderbilt.edu with any questions.

Details

Date:
March 27
Time:
12:00 pm - 1:00 pm UTC-6
Event Category:

Venue

Zoom

Organizer

QSBC Seminar Series

Leave a Reply