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“The Connections Between Enhancer Architecture and Function”

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To carry out an enormous diversity of tasks, proteins can assume a variety of structures or disordered states, and years of work have made the connection between protein sequences, structures, and functions. Enhancers and other pieces of regulatory DNA regulate gene expression in highly disparate biological processes, but we still lack general principles that can […]

Transport Transforms for Data Analysis and Machine Learning

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Based on optimal transport theory, transport transforms are non-linear transforms that are well suited for many applications in data analysis, classification, and processing. In many situations, ranging from machine learning and signal processing, transport-based algorithms have outperformed state-of-the-art methods. In this talk, we will describe the Cumulative Distribution Transform (CDT), the Radon-CDT, and some of […]

Engineering Approaches to Studying Cancer Cell Migration

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During cancer metastasis, cells move from the primary tumor, traversing heterogeneous terrain before seeding within a secondary site. Quantitative systems biology observes this terrain, including changes in tissue stiffness and architecture which can affect cell behavior and metastatic potential. In this talk, I will describe my lab’s efforts to understand the forces driving cell movements […]