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Featurizing Multi-Sample CyTOF Datasets to Predict Clinical and Experimental Phenotypes

Engineering & Science Building 048 Vanderbilt University, Nashville, United States

This talk introduces fully automated featurization or summarization approaches for encoding properties of diverse immune cell-types and their functional states assayed through single-cell immune profiling techniques, such as CyTOF. The algorithms introduced enable compact summarization of each sample profiled in a multi-sample single-cell datasets, such as these representations can be used to predict clinical or […]

Genotype-to-phenotype Mapping with Artificial Intelligence

Engineering & Science Building 048 Vanderbilt University, Nashville, United States

In this talk, I will outline challenges and opportunities associated with learning genotype -> phenotype maps using methods from artificial intelligence. In addition to describing a number of case studies from tumor progression and adverse vaccine reactions to antiviral remittances and gene expression profiling, I will outline a research program that integrates wet-lab and dry-lab […]