Anup Challa is Principal Investigator of Modeling Adverse Drug Reactions in Embryos (MADRE), a collaboration among Vanderbilt, Harvard, and Northwestern that leverages big clinical and drug-specific data to clarify drug safety for pregnant women and their unborn children. He is Cornelius Vanderbilt Scholar and Chancellor’s Scholar in the Accelerated Graduate Program in Chemical Engineering, and […]
Talk Title: "Of kinetochores and centrosomes: mechanism(s) of mitotic spindle assembly."
Alexey Khodjakov to talk about the quantification/modeling of the mitotic spindle (collaboration with Alex Mogilner).
"We are completing characterization of chromosome behavior during prometaphase in human cells. This work involves good microscopy, machine-learning classification of chromosome trajectories, as well as computational modeling of mitotic spindle assembly."
Nandita Garud presents "The Bacteria Within Us" The human gut microbiome is composed of a complex ecosystem of microbes that reside inside of us and play an important role in our health. With estimates of as many as a billion new mutations entering our microbiomes per day, bacterial genomes inside us have a great opportunity to […]
Presenter: Jennifer Oyler-Yaniv, Ph.D. from the Wollman Lab UCLA Zoom Webinar Link: https://us02web.zoom.us/j/87550168229?pwd=QW9rUnBtTG1Ubk41d2Z0a3RhaWJCQT09 Passcode: 268741 The immune system poses a constant challenge to host tissues. On one hand, immune cells are essential for the destruction and clearance of infected or transformed cells. However, damage to bystander tissue is an unavoidable consequence of immune activity. Studying […]
Modern medicine has given us effective tools to treat some of the most significant and burdensome diseases. At the same time, it is becoming consistently more challenging and more expensive to develop new therapeutics. A key factor in this trend is that the drug development process involves multiple steps, each of which involves a complex […]
During cancer metastasis, cells move from the primary tumor, traversing heterogeneous terrain before seeding within a secondary site. Quantitative systems biology observes this terrain, including changes in tissue stiffness and architecture which can affect cell behavior and metastatic potential. In this talk, I will describe my lab’s efforts to understand the forces driving cell movements […]
Based on optimal transport theory, transport transforms are non-linear transforms that are well suited for many applications in data analysis, classification, and processing. In many situations, ranging from machine learning and signal processing, transport-based algorithms have outperformed state-of-the-art methods. In this talk, we will describe the Cumulative Distribution Transform (CDT), the Radon-CDT, and some of […]
To carry out an enormous diversity of tasks, proteins can assume a variety of structures or disordered states, and years of work have made the connection between protein sequences, structures, and functions. Enhancers and other pieces of regulatory DNA regulate gene expression in highly disparate biological processes, but we still lack general principles that can […]
Biological processes can be observed both in space and over time using imaging. Visual assessment becomes limiting as datasets grow, and complexity of data as well as subtleness of processes makes it difficult to draw confident conclusions without automated and quantitative measurement strategies. Traditionally, digital image processing has relied on engineering mathematical models of e.g. […]
Any process can be framed as an algorithm; its power and its limits can then be analysed with the techniques of theoretical computer science. To analyse algorithms, we divide the world in two (i) the problem space that shapes what might happen and (ii) the dynamics of what does happen. If we fix an idealized […]
Event Zoom Link Gene expression involves the precise regulation of messenger RNA (mRNA) transcripts in space and time. In developing embryos, this process must be precisely executed to ensure cells adopt their proper cell fates and developmental outcomes. Dr. Osborne Nishimura's lab explores how mRNA transcripts concentrate within biomolecular condensates or at membranes within the […]
The first response of epithelial cells to local wounds is a dramatic increase in cytosolic calcium. This increase occurs quickly – calcium floods into damaged cells within 0.1 s, moves into adjacent cells over ~20 s, and appears in a much larger set of surrounding cells via a delayed second expansion over 40-300 s – […]