Chemical and Genetic Approaches for Understanding Regulated Cell Death
ZoomPresentation by Michael J. Lee Associate Professor of Systems Biology University of Massachusetts Medical School Zoom Link: https://us02web.zoom.us/j/87550168229?pwd=QW9rUnBtTG1Ubk41d2Z0a3RhaWJCQT09 Zoom Passcode: 268741
Savvy Science: Professionalism Strategies | ASPIRE Bistro for PhD Students
ZoomASPIRE Bistro for PhD Students Aspire for Career Planning The Aspire Team https://medschool.vanderbilt.edu/career-development/aspire-bistro-for-phd-students/
Systems approaches to investigate tumor-fibroblast interactions driving colorectal cancer progression
ZoomShannon Mumenthaler, PhD, is an Assistant Professor of Medicine and Biomedical Engineering at the University of Southern California. ZOOM LINK & Zoom Passcode: 268741
K-Awards: Which One is Right for You? | ASPIRE Café for Postdoctoral Fellows
ZoomASPIRE Café for Postdoctoral Fellows Orientation to ASPIRE Resources for Postdocs Ashley Brady, PhD https://medschool.vanderbilt.edu/career-development/aspire-cafe-for-postdoctoral-fellows/
Informational Interviewing | ASPIRE Job Search Series
ZoomASPIRE Job Search Series https://medschool.vanderbilt.edu/career-development/aspire-job-search-series-for-phd-students-and-postdocs/
Quantifying and Characterizing Cancer Cell Death Kinetics
ZoomPresented by Associate Professor at Stanford University Scott Dixon, PhD. Discussion with students & Postdocs to follow Zoom Webinar: https://us02web.zoom.us/j/87550168229?pwd=QW9rUnBtTG1Ubk41d2Z0a3RhaWJCQT09 Passcode: 268741
Systems Pharmacology Approaches to Measure, Model, Predict and Modulate Cancer Therapeutic Responses
ZoomPresentation by Mohammad Fallahi-Sichani, Ph.D. Assistant Professor of Biomedical Engineering University of Virginia Discussion with students & Postdocs to follow . Zoom Webinar: https://us02web.zoom.us/j/87550168229?pwd=QW9rUnBtTG1Ubk41d2Z0a3RhaWJCQT09 Passcode: 268741
Systems Biology approaches to interrogate roles of long non-coding RNAs in pan-cancer gene expression regulation
ZoomSeema Mishra, Ph.D, is an Assistant Professor, Department of Biochemistry, at University of Hyderabad, India, which is an Institution of Eminence conferred by the Government of India. She has completed her Ph.D in Molecular Biology under Prof. S.E. Hasnain at National Institute of Immunology, New Delhi and trained at Prof. Andrea Califano’s laboratory at Columbia […]
Machine learning: a new approach to drug discovery
ZoomModern medicine has given us effective tools to treat some of the most significant and burdensome diseases. At the same time, it is becoming consistently more challenging and more expensive to develop new therapeutics. A key factor in this trend is that the drug development process involves multiple steps, each of which involves a complex […]
Revealing the diversity and regulatory potential of glioblastoma-derived extracellular RNA
ZoomZoom Link Meeting ID: 170 078 842 Passcode: 345030
Engineering Approaches to Studying Cancer Cell Migration
ZoomDuring cancer metastasis, cells move from the primary tumor, traversing heterogeneous terrain before seeding within a secondary site. Quantitative systems biology observes this terrain, including changes in tissue stiffness and architecture which can affect cell behavior and metastatic potential. In this talk, I will describe my lab’s efforts to understand the forces driving cell movements […]
Transport Transforms for Data Analysis and Machine Learning
ZoomBased on optimal transport theory, transport transforms are non-linear transforms that are well suited for many applications in data analysis, classification, and processing. In many situations, ranging from machine learning and signal processing, transport-based algorithms have outperformed state-of-the-art methods. In this talk, we will describe the Cumulative Distribution Transform (CDT), the Radon-CDT, and some of […]
“The Connections Between Enhancer Architecture and Function”
ZoomTo carry out an enormous diversity of tasks, proteins can assume a variety of structures or disordered states, and years of work have made the connection between protein sequences, structures, and functions. Enhancers and other pieces of regulatory DNA regulate gene expression in highly disparate biological processes, but we still lack general principles that can […]
Image analysis and AI in microscopy-based life science research
ZoomBiological processes can be observed both in space and over time using imaging. Visual assessment becomes limiting as datasets grow, and complexity of data as well as subtleness of processes makes it difficult to draw confident conclusions without automated and quantitative measurement strategies. Traditionally, digital image processing has relied on engineering mathematical models of e.g. […]
“From games in Cancer to endless evolution: a view through the algorithmic lens”
Any process can be framed as an algorithm; its power and its limits can then be analysed with the techniques of theoretical computer science. To analyse algorithms, we divide the world in two (i) the problem space that shapes what might happen and (ii) the dynamics of what does happen. If we fix an idealized […]
Moving the message: how mRNA transcripts are spatially patterned to direct developmental outcomes
ZoomEvent Zoom Link Gene expression involves the precise regulation of messenger RNA (mRNA) transcripts in space and time. In developing embryos, this process must be precisely executed to ensure cells adopt their proper cell fates and developmental outcomes. Dr. Osborne Nishimura's lab explores how mRNA transcripts concentrate within biomolecular condensates or at membranes within the […]
Something’s Wrong in the (cellular) neighborhood: Mechanisms of epithelial wound detection”
The first response of epithelial cells to local wounds is a dramatic increase in cytosolic calcium. This increase occurs quickly – calcium floods into damaged cells within 0.1 s, moves into adjacent cells over ~20 s, and appears in a much larger set of surrounding cells via a delayed second expansion over 40-300 s – […]
Early life microbiota development and childhood asthma – microbes to mechanisms
ZoomA presentation by Susan Lynch Professor of Medicine, Director, Benioff Center for Microbiome Medicine, University of California: San Francisco Zoom link https://us02web.zoom.us/j/87550168229 The prevalence of allergy and asthma has increased significantly over the past several decades, but particularly so in industrialized nations where environmental exposures and lifestyles have rapidly diverged from those with which humans […]
Using Single-Cell Multiplexed Imaging and Manifold Learning to Visualize Cell Cycle Plasticity in Health and Disease
ZoomA Presentation by Wayne Michael Stallaert, Ph.D. Postdoctoral Researcher in Computational Medicine, University of North Carolina at Chapel Hill The recent development of single-cell approaches to study the cell cycle (e.g. time-lapse imaging of fluorescent cell cycle biosensors) has revealed that cells do not always take the same molecular path through the cell cycle. This […]
Precision and Plasticity in Animal Transcription
Over the past decade, our group has focused on discerning the molecular mechanisms that can reconcile how transcriptional control during animal development can be simultaneously precise (e.g. sharp in response to variable inputs) and plastic (e.g. able to harbor genetic variation at multiple scales). I will discuss how our work supports a view of transcription […]
