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The Evolution of Immune System Architecture and Deployment
The Evolution of Immune System Architecture and Deployment
Many pathways involved in innate immunity in plants, insects, and mammals also play roles in host development. This genetic pleiotropy could constrain the ability of immune systems to rapidly evolve in response to selective pressure from microbes because adaptive evolution could negatively affect other developmental processes and thus host fitness. Does pleiotropy constrain adaptive evolution, […]
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Applications of Quantitative Systems Biology and Machine Learning
Applications of Quantitative Systems Biology and Machine Learning
Biotechnology is rapidly improving, largely due to our ability to manipulate genetic material and efficiently measure biological processes. This talk will describe advances in computational approaches and experimental platforms to probe and control stochastic biological processes within individual cells under a microscope. First, I will describe a novel platform for interfacing individual cells with computational models of […]
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Modeling Subcellular Mass Distributions with Optimal Transport: Applications in Cancer
Modeling Subcellular Mass Distributions with Optimal Transport: Applications in Cancer
Microscopic imaging techniques have given us access to high fidelity measurements of subcellular molecule and protein mass distributions. Quantitative analysis of these has the potential to elucidate biological mechanisms as well help perform diagnosis and clinical outcome predictions in cancer and other pathologies. By using the mathematics of optimal transport we can quantitatively compare distributions […]