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Transcriptional stochasticity reveals multiple mechanisms of long non-coding RNA regulation at the Xist-Tsix locus
Transcriptional stochasticity reveals multiple mechanisms of long non-coding RNA regulation at the Xist-Tsix locus
Long noncoding RNAs (LncRNAs) are increasingly recognized as being involved in human physiology and diseases, but there is a lack of mechanistic understanding for the majority of lncRNAs. We comparatively tested proposed mechanisms of antisense lncRNA regulation at the X-chromosome Inactivation (XCI) locus. Our single-cell analyses argue against mechanisms that require the Xist or Tsix […]
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Featurizing Multi-Sample CyTOF Datasets to Predict Clinical and Experimental Phenotypes
Featurizing Multi-Sample CyTOF Datasets to Predict Clinical and Experimental Phenotypes
This talk introduces fully automated featurization or summarization approaches for encoding properties of diverse immune cell-types and their functional states assayed through single-cell immune profiling techniques, such as CyTOF. The algorithms introduced enable compact summarization of each sample profiled in a multi-sample single-cell datasets, such as these representations can be used to predict clinical or […]